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MP3401 / MuRF1 (C-terminal region) Rabbit Polyclonal

¥4,720.00
含13%增值税(专票和普票价格相同)

产品资料详情: ECMbio链接

数量
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原装正品保证

Muscle proteolysis is regulated by the ATP-dependent ubiquitin–proteasome system. This system involves ubiquitination of specific proteins, leading to recognition and degradation by the 26S proteasome complex. Ubiquitination requires interactions with ubiquitin related proteins, ubiquitin-activating (E1), ubiquitin-conjugating (E2) and ubiquitin-ligating enzymes (E3) known as ligases. Two muscle specific ubiquitin ligases have been identified, muscle ring finger 1 (MuRF-1) and Atrogin 1. Both ligases are regulated by the Akt1/FOXO1 signaling pathway, and both proteins have been shown to be upregulated prior to the onset of atrophy in multiple models of muscle wasting, including disuse and cachexia. MuRF1 is also known as TRIM63, SMRZ, and RNF28, and its expression is upregulated after TNFα treatment in C2C12 cells and muscle tissue, while localization of MuRF1 protein has been observed in the cytoplasm and nucleus of cells.

参考文献:

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Marino, F.E. et al. (2015) JCSM.12031 (WB: mouse gastrocnemius)
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MP3401

详细信息

规格
100 ul
抗体宿主
Rabbit
保存温度
冷冻 (-20C)
产地
美国